EGFR and neoplasm: To evaluate these methods, we quantified and compared; (1) RA between treated and untreated mice bearing either EGFR(+) or EGFR(-) tumors using both the model-fitting and snapshot techniques, (2) RA between EGFR(+) and (-) tumor groups using both techniques, (3) single agent uptake in treated and untreated EGFR(+) and (-) tumors at both short and long post-agent-administration times, and assessed (4) the ability of the snapshot RA technique to estimate the model-based RA values.