This is consistent with the inherent biological properties of the models, wherein the DLD-1 cells derived from Duke's type C, p53-mutated, CEA-expressing adenocarcinoma are more invasive and migratory than the RKO cells derived from a p53-, K-Ras-wild type primary carcinoma site 61, 62. The gene discussed is CEACAM5; the disease is adenocarcinoma.