The deregulated expression of Wnt pathway genes including FZD7, DVL1, SFRP4, and SFRP5, found in our study, agrees with similarly deregulated expression of FZD7 and SFRP5 observed in HBV-related HCCs 60, and the upregulated expression of DVL1 in all HCC types 51. Here, SFRP5 is linked to hepatocellular carcinoma.