Reduced DDX5 and SUZ12 protein levels correlate with enhanced viral transcription and replication, while in clinical samples, reduced DDX5 expression correlates with hepatocyte de-differentiation, expression of PRC2 target genes including EpCAM, a hepatic Cancer Stem Cell (hCSC) marker 18, and poor patient prognosis 7. The gene discussed is EPCAM; the disease is liver cancer.