Bm7 and H2981 lung cancer cells treated with EGF exhibited significantly elevated intracellular calcium concentrations compared with those without EGF treatment, whereas BASP1 knockdown significantly attenuated the intracellular calcium response to EGF stimulation, likely due to the downregulation of EGFR (Figure 3H-I and Figure S3F-H). This evidence concerns the gene BASP1 and lung cancer.