EGFR and acute promyelocytic leukemia: To identify agents that can suppress BASP1 expression, we screened a library of traditional Chinese medicines for small compounds that target BASP1 and identified arsenic trioxide (As2O3), which has been used in the treatment of acute promyelocytic leukemia 40, as it decreased BASP1 proteins in CL1-0 and H1975 cells harboring wild-type and mutant EGFR, respectively (Figure S6A).