Importantly, the positive correlation between hsa_circ_0062444 and IL-6, IL-1β or TNF-α was validated in human patients with T1DM, while no correlations between the hsa_circ_0009718 or hsa_circ_0060450 and IL-6, IL-1β or TNF-α were identified (Figure 1E and Figure S2A). The gene discussed is IL1B; the disease is type 1 diabetes mellitus.