Importantly, the TMX-suppressed hepatic VLDL-TG secretion as well as hepatic ApoB, MTP, and PLA2G12B expression were rescued by enforced ERRα expression (Figure 6D-E), strongly implying that reduced ERRα expression is a contributing factor behind the TMX-induced NAFLD. The gene discussed is ESRRA; the disease is metabolic dysfunction-associated steatotic liver disease.