Notably, a previous study also suggested improvement of the tumor uptake by combinatory treatment, whereby co-administration of the neutral endopeptidase inhibitor phosphoramidon (PA) increased the level of circulating radiopeptides, including the gastrin analogue [111In]In-DOTA-MG11, and remarkably enhanced tumor uptake in mouse models 54. The gene discussed is MME; the disease is neoplasm.