Biodistribution analysis in A431/CCKBR tumor-bearing mice demonstrates significant increase (P=0.0057) in the tumor uptake of [177Lu]Lu-PP-F11N in RAD001-treated animals with a ratio [RAD001/Control] of 1.79, whereas metformin treatment increased [177Lu]Lu-PP-F11N uptake only moderately with a ratio [Metformin/Control] of 1.14 and did not reach statistical significance (Figure 5A). This evidence concerns the gene CCKBR and neoplasm.