To explore, more definitively, the role of platelet HMGB1 in the pathogenesis of experimental sepsis, specifically clearance of bacteria from the peritoneum and circulation, these authors generated gene knockout mice with selective deletion of the genes encoding either HMGB1 individually, or the combination of HMGB1/PF4, in megakaryocytes (90). Here, PF4 is linked to Sepsis.