STAT3 and experimental autoimmune encephalomyelitis: Knier et al. (64) found that in experimental autoimmune encephalomyelitis, Ly6G+ neutrophils differentiated into MDSCs in the central nervous system of wild-type mice in a STAT3-dependent manner, controlling the accumulation and activation of B cells in this compartment, and therapeutic interventions that modulate the interaction of MDSCs with B cells might prevent the continuation of the inflammatory response in the central nervous system compartment in chronic autoimmune diseases (where local aggregates of B cells are drivers of immunopathology) (64).