NLRP3 and cryopyrin-associated periodic syndrome: For the 12 NLRP3 related autoinflammatory disease (NLRP3-AID) cases, which were previously known as cryopyrin-associated periodic syndromes (CAPS), the median age of onset was 0.2 months with a range of 0.1 months to 4.8 years, but the median age of diagnosis was 4.0 years with a range of 0.1 months to 20 years.