Patients with renal disease were found to have higher serum levels of prealbumin, anti-scl-70, RF, anti-extractable nuclear antigen (ENA), anti-SSB, anti-SM, urea, creatinine, cystatin C, α1-microglobulin (α1-MG), serum β2-microglobulin, and other molecules. This evidence concerns the gene SSB and kidney disorder.