Similar to LPS transfection, Gate-16−/−Gabarap−/− macrophages among cells lacking single or compound deficiency of GABARAP subfamily members were the most hyper-responsive to Citrobacter koseri, a Gram-negative bacterium whose infection causes caspase-11 inflammasome activation (33) (Figures 1E,F). The gene discussed is GABARAP; the disease is infection.