Various studies have determined that helminth infection and helminth- derived molecules, S.mansoni secreted SEA (43), Schistosoma mansoni egg-derived ω1 recombinant SEA (44), L. sigmodontis antigen (15) play an important role in metabolic disorders by stimulating a T helper 2 (Th2) response and increasing insulin sensitivity. Here, INS is linked to Other metabolic disease.