The centrality measures (degree and betweenness) indicated that UBC, UBQLN4, PTN, ALB, IL2, ONECUT1, VTN, TTR, IFR5, APP, NUP214, RARB, FGFR2, TF, FOXO4, AMBP, DAB2, GRB2, CFH, and SMAD3 were the major Hub genes of the L. jensenii TL2937-mediated transcriptional network in the DSS-treated PIE cells (Supplementary Figure 1B; Supplementary Table 3). The gene discussed is ONECUT1; the disease is interstitial emphysema.