Indeed, differential expression analysis based on the reclassification into three groups (JIA, JIA-uveitis 1, and JIA-uveitis 2, see Figure 2A) identified 41 genes at a FDR of 5%, including IGHD (LRT, Padj = 2.1 × 10–3) and CCR7 (Padj = 3.7 × 10–2) and KCNN4 (LRT, Padj = 4.2 × 10–6), and BAIAP3 (LRT, Padj = 1.3 × 10–4) genes (Supplementary Table S8). The gene discussed is IGHD; the disease is juvenile idiopathic arthritis.