C3 and uveitis: Cluster 3 (C3) represented a gene signature associated with uveitis that includes core B cell genes, including the MS4A1 gene (encoding CD20), Toll-Like Receptors (TLR) TLR7 and CD180 that regulates B cells responses, and ITSN2 a key gene required for antibody formation in B cells (Supplementary Table S6).