Upon infection, and based on the Ly6C expression (20, 22, 26, 28) the cMO/ncMO profile shifted slightly toward a pro-inflammatory profile in TLR4–/– mice (0.64 ± 0.05 uninfected, 0.89 ± 0.079 infected mice, n = 15; p < 0.05), whereas this ratio was higher in MyD88–/– mice (0.68 ± 0.04 uninfected mice, 1.003 ± 0.087 infected, n = 15; p < 0.01), similar to that found in WT.BL10 and WT.BL6 animals. Here, TLR4 is linked to infection.