In agreement with these findings, in human tumors there are various reports of extremely aggressive G-CSF producing tumors in multiple cancer types, such as lung cancer (18, 19), cervical cancer (20), meningioma (21), melanoma (22), breast cancer (8) and prostate cancer (23), demonstrating the important and modulatory effect of G-CSF in tumor progression and metastasis. This evidence concerns the gene CSF3 and Familial prostate cancer.