HBEGF and hydrops fetalis: When comparing HF diet exposed offspring to control samples, Rho family GTPase 1 (Rnd1), TNF receptor superfamily member 12A (Tnfrsf12a), heparin-binding EGF-like growth factor (Hbegf ) and a group of microRNAs, were discretely upregulated in addition to the aforementioned Fbln5. MicroRNAs are non-coding RNA, 19-24 nucleotides in length, that are known to regulate almost all biological processes, including glucose and lipid metabolism, apoptosis, signal transduction, and inflammatory responses (92).