PGF and gestational diabetes: The release of the anti-angiogenic factor sFlt1 presents a significant cause of proteinuria, glomerular endotheliosis and hypertension in obstetric complications through reduction of PlGF and VEGF bioavailability (160) and placental-derived sFlt-1 circulating concentrations are elevated in both PE and GDM pregnancies relative to healthy uncomplicated pregnancies (160, 161).