As shown in Table 2, both in the training and the test datasets, five features (post-1w rGH, post-1w nGH, post-6m rGH, post-6m IGF-1, and post-6m nGH) were significantly associated with the delayed remission of acromegaly patients (p = 0.000–0.049). This evidence concerns the gene IGF1 and acromegaly.