Puram et al., using a murine model of acute myeloid leukemia (AML) and in vitro human cells lines, found that normal and malignant hematopoietic cells harbor an intact robust clock, but the knockout of BMAL1 and CLOCK resulted in an impairment of tumor cells, meanwhile normal hematopoietic function was not affected. Here, BMAL1 is linked to acute myeloid leukemia.