Ectopic expression of miR-217 inhibited TGF-β1-induced EMT by downregulating SIRT1 in chronic pancreatitis and pancreatic cancer (197), while miR-494 inhibited the proliferation, invasion and chemoresistance of pancreatic cancer by regulating SIRT1 and c-Myc (198). Here, MYC is linked to familial pancreatic carcinoma.