Interestingly, demethylating agent 5-Aza-2'-deoxycytidine (5-Aza-dC) and HDAC inhibitor SAHA can also restore miR-34a expression in human pancreatic cancer stem cells (CSCs) and in human pancreatic cancer cell lines and strongly inhibit the cell proliferation, cell cycle progression, self-renewal, epithelial to mesenchymal transition (EMT) and invasion (196). Here, HDAC9 is linked to familial pancreatic carcinoma.