Here, by using immunohistochemical fluorescence and confocal imaging, we aimed at elucidating the CXCL10 expression pattern among pancreatic islet endocrine cells in T1D through the analysis of pancreas samples from NOD, C57Bl/6J and NOD-SCID mice as well as from new-onset T1D patients (DiViD study) and non-diabetic multiorgan donors from the INNODIA European Network for Pancreatic Organ Donors with Diabetes (EUnPOD). The gene discussed is CXCL10; the disease is type 1 diabetes mellitus.