Indeed, triple immunofluorescence staining aimed at detecting insulin, glucagon, and CXCL10 expression in pancreatic sections of 6 new-onset T1D subjects from DiViD study, demonstrated that: (a) in ICIs, both beta- and alpha-cells stained positive for CXCL10 (Figure 5a and Supplementary Figure 6); (b) in IDIs, CXCL10 was expressed only in alpha-cells, since the (whole) signal of the chemokine perfectly overlapped with glucagon (Figures 3K–O and Supplementary Figure 7). Here, INS is linked to type 1 diabetes mellitus.