INS and type 1 diabetes mellitus: Such analysis demonstrated that CXCL10-glucagon colocalization rate was significantly higher compared to CXCL10-insulin [CXCL10-GCG 36.5 ± 17.1% vs. CXCL10-INS 23.6 ± 18.9% (mean ± SD) (Figures 5b,c)], thus demonstrating that alpha-cells significantly contribute, together with beta-cells, to CXCL10 expression in pancreatic islets of T1D subjects.