CXCL10 and type 1 diabetes mellitus: Thirdly, the co-existence of IDI-CXCL10pos and IDI-CXCL10neg indicates a high level of heterogeneity involving also pancreatic islets alpha-cells expressing CXCL10; the identification of those factors determining the expression of CXCL10 in alpha-cells and how these correlate with individual islet phenotype would be of major importance to understand the role of this chemokine in T1D.