GHRL and type 1 diabetes mellitus: Although plasma ghrelin elevates upon STZ administration (Figure 2D) (36, 38, 40, 42) and also although this elevated ghrelin is thought to contribute to STZ-induced hyperphagia (38), changes to plasma ghrelin have not been consistently reported in the literature in type 1 diabetes in humans (33, 68–73) nor is hyperphagia a usual feature of type 1 diabetes in humans.