• Higher concentrations of IL-2, IL-6, IL-1β, IL-17# • Covariation of TNF-α and IL-12 plasma concentrations and tic/OCS severity# • Correlation of IL-2 concentrations with tic severity# • Higher concentrations of neopterin# • Higher concentrations of IL-1β, MCP-1 and IP-10 in patients with acute exacerbation of tics requiring hospitalization#. Here, TNF is linked to tic disorder.