Weidinger et al. (88) documented an impairment of innate responses in a cross-sectional study that compared 33 TS patients to 31 healthy subjects, showing lower receptor expression of toll-like receptor 4 (TLR4) after stimulation with lipopolysaccharide (LPS), and higher levels of soluble Cluster Differentiation (CD)14. Here, TLR4 is linked to Timothy syndrome.