In fact, the pathogenic PD mutations LRRK2 G2019S and α-synuclein A53T disrupt this process, resulting in Miro1 accumulation, delayed mitochondria arrest, and impaired mitophagy activation in patient-derived fibroblasts and induced pluripotent stem cell (iPSC)-derived neurons (11, 12). Here, LRRK2 is linked to Parkinson disease.