Moreover, in our studies, we were able to observe a reduced co-localization of Miro1 with MERCs in Miro1-mutant fibroblasts from PD patients compared to control fibroblasts (14) and, conversely, an increased co-localization of Miro1 with MERCs in Miro1-R272Q iPSC-derived neurons (67), underscoring the importance of Miro1 localization to MERCs and a potential role in neurodegeneration. Here, RHOT1 is linked to Parkinson disease.