Conversely, increased myocardial PPARβ/δ may be protective against obesity/T2D-related cardiomyopathy, as cardiac-specific overexpression of PPARβ/δ prevents cardiac dysfunction following 8 weeks of high-fat diet supplementation (Burkart et al., 2007). The gene discussed is PPARD; the disease is obesity due to melanocortin 4 receptor deficiency.