In particular, supplementation of the drinking water for 4 weeks with DCA (1 mM), augmented myocardial PDH activity and glucose oxidation rates in male Wistar rats subjected to experimental T2D via high-fat diet supplementation and low-dose streptozotocin (25 mg/kg) administration (Le Page et al., 2015). The gene discussed is PDP1; the disease is type 2 diabetes mellitus.