PPARα may also potentially be a key mediator of the increased reliance on TAG-derived fatty acid oxidation in obesity/T2D, as 13C nuclear magnetic resonance spectroscopy studies revealed increased TAG turnover in cardiac-specific PPARα overexpressing male mice fed a high-fat diet for 2 weeks (Banke et al., 2010). The gene discussed is PPARA; the disease is obesity due to melanocortin 4 receptor deficiency.