AGT and cardiac hypertrophy: In addition, infusion of angiotensin II (1.5 mg⋅kg–1⋅day–1), a potent vasoconstrictor and mediator of cardiac injury, for 14 days via implanted micro osmotic pumps in male C57BL/6J mice induces cardiac hypertrophy and diastolic dysfunction (Mori et al., 2012).