With regards to impaired myocardial glucose utilization in obesity/T2D, cardiac myocytes isolated from adult ob/ob and db/db mice exhibit reduced insulin-stimulated Akt phosphorylation and 2-deoxyglucose uptake (Mazumder et al., 2004; Hafstad et al., 2006). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.