Reductions in MCU activity may also be involved, as C57BL/6NHsd mice subjected to experimental T1D via 5 daily injections with streptozotocin (40 mg/kg) exhibit decreased myocardial MCU protein expression and mitochondrial calcium levels in intact-paced contracting cardiac myocytes (Suarez et al., 2018). The gene discussed is MCU; the disease is type 1 diabetes mellitus.