SHH and Ureteral obstruction: Zhou et al. (2014) identified interstitial fibroblasts to be the targets of renal SHH signaling. Incubation with SHH or SHH overexpression promoted kidney fibroblast proliferation and stimulated expression of numerous proliferation-related genes. One study (Ding et al., 2012) also found that in ureteral obstruction model, SHH localized predominantly to the renal tubular epithelium.