The benefit of short-term (12–30 weeks) SGLT2i/GLP1-RA combination therapy in patients with T2D was further confirmed in a meta-analysis (1,913 patients) of seven trials, which revealed the greater reduction in HbA1c, bodyweight and systolic blood pressure compared to GLP1-RA or SGLT2i therapy (Mantsiou et al., 2020). The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.