NPPB and angina pectoris: HF represents a manifold disease, which is diagnosed based on the ejection fraction (EF), the presence of signs or symptoms such as reduced exercise capability or angina pectoris, structural changes in the heart, or the elevated levels of natriuretic peptides, especially brain natriuretic peptide (BNP)/N-terminal pro-brain natriuretic peptide (NT-proBNP) (Cosentino et al., 2020).