Ezogabine, an FDA-approved drug that increases Kv7.2/7.3 currents by shifting voltage activation to more hyperpolarized voltages and increasing maximal current density, has been proposed as a targeted therapeutic in KCNQ2 encephalopathy and use with some apparent benefit has been described in small clinical case series, including in the A337T proband (Gunthorpe et al., 2012; Millichap and Cooper, 2012; Weckhuysen et al., 2013; Millichap et al., 2016). The gene discussed is KCNQ2; the disease is Encephalopathy.