Previous studies have shown that ACE DD had close association with a high incidence of cardiovascular disease or endothelial dysfunction (Alvarez et al., 2001; Brand and van der Schouw, 2010; Kuzubova et al., 2013; Al-Hazzani et al., 2014; Amara et al., 2018). The gene discussed is ACE; the disease is endothelial dysfunction.