Recent studies have shown that the activation of the NLRP3 inflammasome is involved in the progression of various inflammatory diseases, such as type 2 diabetes, atherosclerosis, and Muckle-Wells syndrome (Duewell et al., 2010; Lamkanfi and Dixit, 2012; Kong et al., 2017). The gene discussed is NLRP3; the disease is type 2 diabetes mellitus.