In pancreatic cancer, integrin αvβ3 interacted with osteopontin on pancreatic stellate cells, which led to the activation of αvβ3-Akt/Erk-FOXM1 (forkhead box protein M1) cascade and promoted CSC-like properties of pancreatic cancer (Cao et al., 2019). Here, SPP1 is linked to familial pancreatic carcinoma.