ANG is a major inducer of tRNA halves (Thompson et al., 2008; Fu et al., 2009; Yamasaki et al., 2009; Su et al., 2019), and several studies suggest ANG is involved in cardiac hypertrophy and heart failure (Patel et al., 2008; Jiang et al., 2014; Yu et al., 2018; Oldfield et al., 2020). The gene discussed is ANG; the disease is heart failure.