Compared with other viral infection, SARS-CoV-2 causes high proinflammatory disease state associated with COVID-19 through inducing lower levels of IFN–I and –III expression with a moderate reaction of IFN-stimulated genes (ISGs) and raising chemokine expression (Figure 4) (Blanco-Melo et al., 2020). The gene discussed is IFNA1; the disease is viral infectious disease.