IL1B and malignant colon neoplasm: IL-1β is known to stimulate diarrhea, immune cell infiltration, and intestinal necrosis, and IL-6 reduction had shown to slow down the development of UC and colitis-associated colon cancer (Papadakis and Targan, 2000; Perrier and Rutgeerts, 2011; Moriasi et al., 2012; Song et al., 2013).