Among them, GSK3β has received more attention because of its central role in the regulation of many important metabolic and signaling proteins, structural proteins and transcription factors, that depicts GSK3β as a promising target for the treatment of cancer, neurodegenerative diseases, neuropsychiatric diseases, and other major diseases (Cohen and Frame, 2001; Osolodkin et al., 2013; O’Leary and Nolan, 2015; Maqbool and Hoda, 2017; Abdul et al., 2018). This evidence concerns the gene GSK3B and neurodegenerative disease.