AGT and renovascular hypertension: AngII, the major effector peptide of the renin-angiotensin-aldosterone system (RAAS), increased the production of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, especially superoxide anion (O2 -), in a rat model of renovascular hypertension (Oliveira-Sales et al., 2009) via activating AngII type I receptor (AT1R).