FGFR1 and lung cancer: In our previous study, a series of symmetric structural analogues of nordihydroguaiaretic acid (NDGA), a phenolic compound isolated from the creosote bush, was constructed and it was found that Af23 (IC50 = 1.4 μM) was a non-ATP-competitive FGFR1 inhibitor with excellent anti-lung cancer activity in vitro and in vivo (Wu et al., 2015).