AKT1 and cancer: Figure 5A showed that Y14 displayed significant inhibitory effect on FGF-2 induced phosphorylation of FGFR1 in SGC-7901 and BGC-823 cells with a dose-dependent manner. Furthermore, we observed that pretreatment with Y14 for 2 h significantly suppressed FGF2- induced activation of the main downstream effectors of FGFR1, such as p-ERK and p-AKT (Figure 5A). It is suggested that Y14 may have anti-cancer and chemosensitizing effects on gastric cancer by inhibiting FGFR1 phosphorylation and its downstream signaling pathway.