The deregulated vascular system in the eyes and kidneys from T1DM patients has been suggested to be affected by several factors including the duration of diabetes and deregulation of several signaling factors such as vascular endothelial growth factor (VEGF), TGF-β1, and angiogenin (Zorena et al., 2009). The gene discussed is VEGFA; the disease is type 1 diabetes mellitus.