Examination of the classical autophagy markers, LC3II and LAMP2, revealed a remarkable rise in LC3-II and LAMP-2 mRNA expression in subjects with prediabetes (Rovira-Llopis et al., 2015), while patients with NDT2DM and ADT2DM showed the significant reduction in both LC3II and LAMP2 mRNA and protein expression. The gene discussed is LAMP2; the disease is prediabetes syndrome.