AKT1 and breast cancer: It has been demonstrated that MT effectively inhibited the invasion of highly-metastatic human breast cancer MDA-MB-231 cell in vitro by reducing the activation of MMP-9/MMP-2, enhancing the phosphorylation of AKT, and decreasing the activities of p-65, VEGFR1, and epidermal growth factor (EGF) (Yu P., et al., 2009).