SQSTM1 and acute myeloid leukemia: In acute myeloid leukemia cell lines (HL-60, THP-1 and C1498), treatment with MT at doses of 0.25-3 g/L for 12-48 h resulted in cytotoxicity via induction of Akt/mTOR signaling inhibition-mediated apoptosis and autophagy, which is involved in increased expression of LC3-II and decreased SQSTM1/p62 ratio (Wu J. et al., 2017).