INS and Glucose intolerance: Furthermore, it has been reported that MT (100 mg/kg/day for 4 weeks) effectively reduced glucose intolerance and plasma insulin levels in high-fructose-fed mice by inhibiting endoplasmic reticulum (ER) stress-associated de novo lipogenesis (DNL) and increasing HSP72 protein expression in the liver (Mahzari et al., 2018).