TP53 and colonic neoplasm: Ye et al. (2015) also showed that the curcumin proapoptotic effect depends on miR-192-5p and miR-215, which activates the p53 in non-small cell lung cancer. Other studies have shown that curcumin-triggered apoptosis is p53-independent in HT-29 colon cancer cells (Watson et al., 2010).