MTOR and Hepatic fibrosis: Curcumin administration in Sprague-Dawley rats with CCl4-induced hepatic fibrosis led to a decrease in liver fibrosis through: i) reducing extracellular matrix overproduction in HSCs; ii) disrupting PDGF-R/ERK and mTOR pathways; iii) activating PPAR-γ; iv) upregulating PTEN and miR-29b expression; and v) downregulating cannabinoid receptors (CBR) type 1 and DNA methyltranferase 3b (Chen et al., 2014; Zhang et al., 2014).