In this review article, we focus exclusively on the process of α-synuclein (α-Syn) accumulation and aggregation, the pathological hallmark of a group of diseases like Parkinson’s disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies (DLB), commonly known as α-Synucleinopathies (Duda et al., 2000; Goedert et al., 2017). The gene discussed is SNCA; the disease is Lewy body dementia.