HDAC6 and Parkinson disease: The association between HDAC6 and the pathogenesis of α-Synucleinopathies emerged when histopathological analysis in brain sections from PD patients revealed highly concentrated expression of HDAC6 within LBs, suggesting a possible role of HDAC6 in the formation of such inclusions (Kawaguchi et al., 2003; Miki et al., 2011).