In case of chronic neurodegenerative diseases such as Alzheimer’s or Parkinson’s disease, physiological levels of zinc or AMPK activity may promote cell survival through the enhancement of lysosomal function and the resultant reduction of protein aggregates accumulation (Park et al., 2011; Lee et al., 2017; Jang et al., 2018). The gene discussed is PRKAA2; the disease is Parkinson disease.