Parkin, an E3 ubiquitin ligase, plays a neuroprotective role in neurodegenerative diseases through various processes, such as the degradation of neurotoxic proteins via the ubiquitin-proteasome system (UPS) and ERAD, and suppression of P53 transcription (Nakamura et al., 2013). This evidence concerns the gene PRKN and neurodegenerative disease.