SLC25A27 and Parkinson disease: Brain UCP4 mRNA expression was shown to be upregulated after acute exposure to temperatures of 4°C (Yu et al., 2000), and UCP4 overexpression has been shown to prevent ATP deficiency and oxidative insult in PD cell models (Chu et al., 2009; Wu et al., 2014; Xu et al., 2018).