In addition, our results indicated that preventing persistent brain hypothermia through exercise (Figure 2) or cold exposure (Figure 3) is associated with the improvement of MPTP-induced nigrostriatal dopaminergic neurodegeneration (loss of THir neurons in the SN and reduction of DAT immunoreactivity in the striatum, Figure 6) and movement disorders (short latency to fall in rotarod performance, Figure 5). The gene discussed is SLC6A3; the disease is movement disorder.