UCP2 upregulation was also found to be important in terms of providing the benefits of exercise in neurodegenerative diseases via a comparable effect of UCP4 and UCP5 in the reduction of oxidative stress (Chu et al., 2009; Kwok et al., 2010; de Oliveira Bristot et al., 2019). The gene discussed is UCP2; the disease is neurodegenerative disease.