APP and Alzheimer disease: ADtg rodent models, including Tg2576, APP/PS1, 3xTg, 5xFAD mice, TgF344-AD rat, and O. degus, show cerebral accumulation of soluble and insoluble Aβ with age, corresponding to AD-like progression (Dutescu et al., 2009; Liu et al., 2009; Perez et al., 2009; Alexandrov et al., 2011; Koronyo-Hamaoui et al., 2011; Williams et al., 2013; Edwards et al., 2014; Park et al., 2014; Tsai et al., 2014; Du et al., 2015; More and Vince, 2015; Parthasarathy et al., 2015; Pogue et al., 2015).