MAPT and Alzheimer disease: Neuroinflammation in AD is linked with increased astrocyte and microglia reactivity and neurotoxicity, Aβ and tau seeding and propagation, as well as with microglia-mediated synaptic pruning (Cardona et al., 2006; Wyss-Coray, 2006; Stevens et al., 2007; Fuhrmann et al., 2010; Lee et al., 2010; Wyss-Coray and Rogers, 2012; Hong et al., 2016; Salter and Stevens, 2017; Ising et al., 2019; Friker et al., 2020).