To investigate whether miR-924 inhibited NSCLC cell proliferation, migration and invasion by mediating RHBDD1, H1299 or A549 cells were selected to transfect with si-NC, si-RHBDD1, miR-924 mimic or miR-924 mimic plus RHBDD1, respectively. The gene discussed is RHBDD1; the disease is non-small cell lung carcinoma.