Previous studies conducted in our laboratory showed that glucose 6-phosphate dehydrogenase (G6PD), which is the first and rate-limiting enzyme of the pentose phosphate pathway (PPP) and plays critical roles in the generation of nucleotide precursors, lipid synthesis, redox balance, and maintenance of the whole cell metabolic homeostasis [16, 17], is highly expressed in ccRCC cells and predicts the poor overall survival of patients with ccRCC, indicating that G6PD exerted crucial functions in ccRCC metabolic reprogramming and tumorigenesis [18]. This evidence concerns the gene G6PD and nonpapillary renal cell carcinoma.