NFKB1 and nonpapillary renal cell carcinoma: The present study suggested novel proliferation strategies of ccRCC cancer cells via dual oncogenic transcriptional factors, NF-κB and STAT3, which are over-activated in ccRCC and cooperatively facilitate ccRCC proliferation through inducing G6PD overexpression and then cell cycle regulators such as CyclinD1 and CDK4.