The present study suggested novel proliferation strategies of ccRCC cancer cells via dual oncogenic transcriptional factors, NF-κB and STAT3, which are over-activated in ccRCC and cooperatively facilitate ccRCC proliferation through inducing G6PD overexpression and then cell cycle regulators such as CyclinD1 and CDK4. This evidence concerns the gene CDK4 and nonpapillary renal cell carcinoma.