Interestingly, previous studies determined that IGFBP3 was a target mRNA of miR-196b, miR-1290, miR-384, miR-34/449 and miR-155 in cancers [37–40], but the regulatory mechanism of miR-409-3p/IGFBP3 has not been verified in OS. Here, IGFBP3 is linked to cancer.