One study revealed that low adiponectin levels were associated with GERD severity scores as defined by videoesophagography in obese subjects, and another study showed a reverse correlation between adiponectin levels and the severity of EE in men.(18,19) In a recent study, the adiponectin levels of 23 men with EE were lower than those of 8 men without EE; this finding was not detected in women.(20) However, these studies had some methodological limitations such as only included men and applied only univariate analyses. Here, ADIPOQ is linked to gastroesophageal reflux disease.